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Lifetime Study Explores Role of Genes and Other Factors in the Development of Cancer
Genes offer valuable clues that can help researchers develop effective treatments for many types of diseases, including cancer. The Morris Animal Foundation's Golden Retriever Lifetime Study is examining how various factors, including environment, genes, nutrition and lifestyle, affect a dogs' cancer risk. Researchers are studying 3,000 golden retrievers in what they report is the largest observational study ever attempted in veterinary medicine.
Because the dogs will be followed throughout their entire lives, it will be a while until results are reported, but the study offers an excellent opportunity to determine why some dogs develop cancer and others do not. Researchers expect study results to provide valuable information that will help them develop better prevention, diagnosis and treatment options for dogs with cancer. Results from the study may also help doctors develop effective cancer treatments for humans too.
For years, pet owners have disagreed about whether purebred or mixed breed dogs are healthier. Until recently, there was no scientific data to back up their opinions, but UC Davis researchers recently helped answer the question with a landmark health study.
Pet owners who thought that mixed breed dogs were healthier argued that inbreeding in purebred dogs increased the likelihood of genetic disorders. Other owners felt that purebred dogs were healthier because many start their lives in professional breeding facilities and are not exposed to infectious diseases that may circulate through animal shelters.
Hip Dysplasia Is a Purebred Problem - Or Is It?
Hip dysplasia is often used as the prime example of an inherited health problem that primarily affects purebred dogs. The condition, which occurs due to a malformation of the ball and socket joint in the hip, causes pain and weakness in the hind legs and can increase the risk of osteoarthritis. Contrary to popular belief, the UC Davis revealed that hip dysplasia was just as likely to occur in mixed breed dogs as it was in purebreds.
Other Disorders with Similar Rates in Both Purebreds and Mixed Breeds
Researchers reviewed the records of 90,000 dogs who were patients of the UC Davis veterinary teaching hospital from 1995 to 2010. In addition to hip dysplasia, they noted that a number of other genetic disorders occur equally often in both groups. They include:
Disorders More Common in Purebred Dogs
Some disorders were more common in purebreds, although the chance that your dog will develop these disorders depends on its breed. For example, large dogs like Saint Bernards and Great Danes are most likely to suffer from bloat. The disorders include:
What About Mixed Breed Dogs?
Cranial cruciate ligament rupture was the only disorder more likely to occur in mixed breed dogs. The ligament helps keep the knee joints in the hind legs stable.
What Is the Bottom Line?
Although purebred dogs do have a higher incidence of some inherited disorders, they are no more likely to develop many serious health conditions, such as cancer, heart disorders and endocrine disorders, than mixed breed dogs. It's crucial to ask questions about health when you consider adding another pet to your family, but it's equally important to consider the animal's temperament, personality, ability to get along with your other pets and the dog's fit with your family.
Regular veterinary care is the key to keeping your purebred or mixed breed dog healthy. If it's been a while since your dog has seen a veterinarian or if your pet is experiencing a health problem, call us today to schedule an appointment.
Healthy Pets: The Surprising Truth About Mixed Breed Dogs, 7/5/13
Mercola: Prevalence of Inherited Disorders Among Mixed-Breed and Purebred Dogs, 6/1/13
Dogs Naturally: Are Mixed Breed Dogs Healthier Than Purebreds?
The Mercury News: San Jose Dogs, Owners Join DNA Studies to Help Find Cures, 3/20/16
Morris Animal Foundation: Canine Lifetime Health Project
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